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The 15 Benefits of CBD

By Yes.Life | 17 January 2020 | 10 min read

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Research on CBD is still early, but it has already demonstrated some incredible benefits. In this article, we’ll quickly go over 15 of the wonderful benefits that CBD has to offer, before wrapping up with how to get the most out of your CBD products.

Anxiety:

CBD is a known anxiolytic, meaning it can help reduce anxiety.1 The methods of this are still under investigation, although a few mechanisms are known. CBD can interact with TRP channels – special little gateways into the cell – that appear to involve at least some anti-anxiety ability.2 CBD is also known to lower levels of cortisol – a major hormone involved in symptoms of stress.3

Finally, CBD can help modulate your stress by boosting the natural levels of anandamide in your body. 4Anandamide is like a human-body version of CBD, made naturally when you go running (i.e. the runner’s high!). 5It is known to interact with special CB1 cell receptors in the brain, where it suppresses both GABA – the inhibitory molecule – and glutamate – the excitatory molecule. 6 7 A depression in glutamate levels is known to lower anxiety and stress, causing relaxation.

Depression:

CBD can also help with depression. 1 In a similar manner to help with anxiety, CBD once again relies on your natural chemical – anandamide – to accomplish this. Anandamide lowers both GABA and glutamate levels in the brain. What does this mean? It means it can help relieve stress if you have too much glutamate, and it can help pick you up if you have too much GABA!6 An imbalance of GABA and glutamate have been implicated in various mood disorders including depression, and CBD is said to help put the brain back in balance.8 9 Rather than push you from one extreme to another, CBD can help you reach a nice, peaceful middle ground.

Acne & Skin Health:

CBD is known to have a very positive effect when it comes to acne. Acne is a result of various skin processes, many involving sebocytes, cells that produce an oily substance known as sebum. This can be done as a result of – say – extra oil production, inflammation, or due to the presence of certain bacteria. Not only does CBD act as an antibiotic, but it can also help regulate sebocytes! CBD has shown an ability to stop lipogenesis – the creation of oils like sebum – and it has broad anti-inflammatory action. It has demonstrated some capable of not just preventing acne, but helping it in late stages as well.10

CBD is also considered a general skin-promoting agent via its activation of TRP channels. TRP channels (Transient Receptor Potential channels) are an assortment of gateways into the cell. Many different things can bond to and open them up, including CBD. They help regulate many things, particularly in the nervous system and in the skin. CBD is known to affect several TRP channels, and research has shown it has a general homeostatic effect on the skin. In other words, it helps your skin maintain its best health.11

Back Pain and Sore Muscles:

CBD is known to provide pain relief.12 One of these methods involves the aforementioned TRP channels. Certain TRP channels will open when they are deformed, such as from something smacking into the skin or body. They send an electric signal to the nervous system as a result, which carries on up to the brain and delivers the message of “pain.” CBD can help nullify this pain by binding onto certain TRP channels and desensitizing them.11

Topical CBDs can help bring rather quick relief to aching muscles or a painful back. However, there can be more to these pains than meets the eye. CBD may be able to help further by its anti-inflammatory actions.13 If chronic pain is an issue, consider using an oral CBD oil for several weeks – this can help the CBD get into the deeper parts of the body and muscles and provide anti-inflammatory and even anti-oxidant effects.14

Eczema:

Little specific research on CBD and eczema is currently available. However, CBD’s anti-inflammatory and skin-promoting effects make it a powerful candidate for eczema treatment.11 13For atopic eczema – that is, inflammation of the skin involving the immune system – CBD has immunosuppressant effects.15 Topical CBD products applied to the trouble areas should provide not just relief, but also help heal the problem. Doubling down with an oral product can help deal with the problem from the inside-out. Whether CBD fully treats eczema remains to be seen, but there is strong potential for it.

Hormone Regulation:

Research has yet to determine the full extent of how CBD affects hormones in general.16 However, it has demonstrated definitive hormone regulation. In fact, we brought this up before: GABA and glutamate, as well as cortisol, are all hormones.

CBD has a further effect on many of the hormones that act in the brain as neurotransmitters, such as serotonin, acetylcholine, and even dopamine.7 Whether CBD has any major effect on other hormones of the body is yet to be seen, although it should be pointed out that CBD’s incredibly safe profile suggests that, at the very least, it shouldn’t have a very damaging effect for most people.16

Irritability:

As part of CBD’s natural balancing of the brain, irritability is brought down. This has been noted particularly as a useful part of CBD’s repertoire for those attempting to quit smoking: the nicotine withdrawal effects involve strong irritability, and CBD has a great capacity to help such symptoms out.17

Sleep:

CBD has plenty of anecdotal evidence suggesting it helps with sleep. Scientifically, it has been shown to improve sleep for many people in at least the first month of use.18 However, results varied after that first month. Some people find it useful to get off CBD for a bit after they have improved their sleep, and only get back on it if they find themselves struggling again. Others simply follow a cycle of on-and-off, attempting to keep the CBD from ever hitting that strange post-month wall. Either way, CBD should be able to help sleep, at least for a good while (and most CBD products come in a one month supply anyway).

How CBD promotes sleep is not well understood. Theories can range from its anti-oxidant effect to its simple relaxing effect as a result of glutamate being suppressed.6 14 For now, we at least know it can help, and science will continue working behind the scenes to learn more!

Heart Health:

It may seem surprising, but early data is suggesting CBD has a positive effect on the heart!19 Much of this seems to stem from its anti-inflammatory and anti-oxidant actions.13 14 CBD also has a vasorelaxant effect, meaning it “relaxes” the blood vessels, and it has shown to improve the cardiovascular response to general stress.19 Interestingly, many of these effects don’t directly target the heart, but the heart still benefits from it all, helping to showcase just how well CBD does promote better health.

Diabetes Prevention:

The progression of diabetes is complicated, although inflammation and oxidative stress are known to play a powerful role in it. CBD – with its anti-inflammatory and anti-oxidant capabilities – has naturally emerged as a potential prevention strategy for diabetes.13 14 While research is still early, it has been shown in models of mice to both lower the incidence of diabetes (in non-obese rats) and even help ameliorate diabetes at the first onset of symptoms.20 To suggest that CBD will keep you from developing diabetes is still far too early to say, but it does have some interesting potential, as shown.

Reducing Inflammation:

CBD is known to have many anti-inflammatory actions, and if you get a product that comes packed with its sister cannabinoids (as any good CBD product should) you’ll get even more weaponry to fight inflammation. CBD and other cannabinoids can fight inflammation in a number of ways. One way involves suppressing the chemical messengers that tell your body to perform inflammation (cytokines).13 Others involve CBD nullifying immune cells that have, essentially, gone rogue and are causing inflammation in places they should never have been in, to begin with.13 21 Finally, CBD has a strange but wonderful ability to induce apoptosis (cell suicide) for cells that are causing problems.15 22 This can prevent inflammation from beginning around these otherwise defective cells.

Non-Habit Forming & Safe

CBD has not been shown to be addictive in any way. In fact, CBD may be able to help people overcome certain addictions with its modulating effect on dopamine and glutamate.7 CBD has a vast safety profile which includes a potent lack of side-effects, especially when compared to many pharmaceuticals.16 Even so, it never hurts to check with your doctor before using CBD – after all, they’ll know your medical history best!

Arthritis:

Arthritis is a powerful form of inflammation that affects the joints of the body. CBD can fight against inflammation, and provide relief for many kinds of arthritis.13 It has been shown to specifically ease the pain associated with arthritis, even in cases where it couldn’t fully cure it.12 This brings up an important point: CBD will likely help the inflammation, but sometimes the body has sustained too much damage. Look forward to CBD’s benefits, but keep in mind it isn’t a perfect panacea – it won’t magically cure everything!

Reduces Nausea:

CBD is known to have very few side-effects, although it is important to note that one of them involves nausea.16 Strangely enough, some scientists hypothesize that CBD – administered with THC as well – may be able to help the vomiting and nausea associated with chemotherapy.23 Other research has suggested that CBD possesses anti-emetic properties.16 It may seem strange given one of its few known side-effects, but the science speaks for itself!

Autoimmune Diseases:

CBD is considered an immunosuppressant.15 This means it pushes down some of the activity of the immune system. Don’t worry: this doesn’t mean you’ll suddenly get horribly sick by taking it. Plenty of research has demonstrated CBD’s safety.16 It does, however, lend itself well to helping autoimmune diseases.

CBD can actually help prevent some autoimmune diseases from starting. As mentioned before, CBD can cause trouble cells in the body to kill themselves before they cause bigger issues, and one of these issues can involve convincing the immune system to attack the body itself.13 CBD can also nullify the activity of the immune system’s major police force, T-cells. Diseases like Multiple Sclerosis (MS) involve T-cells entering parts of the body they were never meant to be, and they naturally start attacking things for no good reason. CBD can help prevent MS by nullifying these T-cells, preventing them from doing any damage. It likely won’t heal the damage already done, but it can keep things from getting worse.

There are many kinds of autoimmune diseases, so if you are more interested in whether CBD can help you or not, please take a look at the following articles: What Does CBD Do and How Does CBD Help Those Suffering From Fibromyalgia. It is worth pointing out that CBD may make some autoimmune diseases worse rather than better, like Celiac’s Disease. However, research on this topic is still early, so don’t necessarily give up hope yet!

How to Use CBD Most Effectively:

Not all CBD products are the same. As more and more people try to enter the CBD market, many of them are trying hard to just cash in on what some consider the current “CBD fad.” They put incredibly cheap, ineffective products out there and charge an arm and a leg for them, hoping to get a slice of the CBD financial pie. So, how can you tell a good product from a bad one?

The most important aspect of any good CBD oil product is whether it is water-soluble. If you already have a product, go ahead and put a little bit of it in water and see if it can mix at all. If it can, great! You have a water-soluble product. If not – if it just separates out like ordinary oil – then your product is not so good. Water solubility is important because you are mostly made of water. Oils are processed through the body very differently compared to other substances, and if you want your body to actually absorb and use the CBD you’ve ingested, it’s going to need the ability to dissolve in you.

With a water-soluble product in hand, you should be able to get a large amount of it in your bloodstream just by holding it under the tongue. Do so for about 15 to 30 seconds. This avoids the otherwise slow and ineffective absorption that can come from the intestines, and it circumvents the first-pass metabolism by the liver, which ordinarily would make most of the CBD you do absorb uselessly. All in all, a simple 250 mg water-soluble CBD product can easily be compared to a 3000 mg CBD product that isn’t water-soluble. And it will be significantly more affordable too! In fact, 250 mg is all most people need from a water-soluble product: take just 1 or 2 ml a day (in the morning, at night, both, however, you want to split it up) and you should be fine. If you feel foggy, take a little less; if nothing seems to be happening for a few weeks, take a bit more. Don’t be afraid to contact the seller with any questions as well – a good CBD company, such as Yes.Life, will be more interested in helping you find a product that works than just getting your money.

If you’re suffering from more chronic problems, consider using a CBD oil tincture (the “drops”). Stick with the product for at least two weeks – and in some cases, it can take up to four weeks for it to reach its full effect. If you are hoping to help inflammation or even mood disorders like anxiety and depression, taking the tincture for weeks at a time is the best method. If you are looking for immediate pain relief, then consider CBD gels and creams designed for pain. No matter what, all products should be water-soluble – again, you are mostly made of water.

Yes.Life features both topical and oral products, all of which meet that water-solubility criterion. Furthermore, Yes.Life offers a 30-day money-back guarantee, giving you enough time to fully test the product before determining whether it really won’t work for you or not. The oral products come well-flavored to help with keeping them under the tongue (CBD is otherwise notoriously disgusting) which by itself makes Yes.Life CBD some of the best out there. Don’t wait around: if you think CBD can offer you something great, head on over to http://Yes.Life right now and order CBD for yourself. If you think it can help, it probably can!


References:

1 Schier, Alexandre, et al. “Antidepressant-Like and Anxiolytic-Like Effects of Cannabidiol: A Chemical Compound of Cannabis Sativa.” CNS & Neurological Disorders - Drug Targets 13, no. 6 (2014) : 953–960., doi:10.2174/1871527313666140612114838.

2 Blessing, Esther M., et al. “Cannabidiol asa Potential Treatment for Anxiety Disorders.” Neurotherapeutics 12, no. 4 (2015): 825–836., doi:10.1007/s13311-015-0387-1.

3 Shannon, Scott. "Cannabidiol in Anxiety and Sleep: A Large Case Series.”The Permanente Journal (2019) doi:10.7812/tpp/18-041.

4 Leweke, F M, et al. “Cannabidiol Enhances Anandamide Signaling and Alleviates Psychotic Symptoms of Schizophrenia.” Translational Psychiatry 2, no. 3 (2012). https://doi.org/10.1038/tp.2012.15.p.2012.15.

5 Fuss, Johannes, et al. “A Runner’s High Depends on Cannabinoid Receptors in Mice.” Proceedings of the National Academy of Sciences 112, no. 42 (2015) : 13105–13108., doi:10.1073/pnas.1514996112.

6 Rey, Alejandro Aparisi, et al. “Biphasic Effects of Cannabinoids in Anxiety Responses: CB1 and GABAB Receptors in the Balance of GABAergic and Glutamatergic Neurotransmission." Neuropsychopharmacology 37, no. 12 (January 2012): 2624–34. https://doi.org/10.1038/npp.2012.123.

7 Castillo, Pablo E., et al. “Endocannabinoid Signaling and Synaptic Function.” Neuron 76, no. 1 (2012) : 70–81., doi:10.1016/j.neuron.2012.09.020.

8 Luscher, B, et al. “The GABAergic Deficit Hypothesis of Major Depressive Disorder.” Molecular Psychiatry 16, no. 4 (2010) : 383–406., doi:10.1038/mp.2010.120.

9 Jun, Chansoo, et al. “Disturbance of the Glutamatergic System in Mood Disorders.” Experimental Neurobiology 23, no. 1 (2014): 28., doi:10.5607/en.2014.23.1.28.

10 Oláh, Attila, et al. “Cannabidiol ExertsSebostatic and Antiinflammatory Effects on Human Sebocytes.” Journal of Clinical Investigation 124, no. 9 (2014) : 3713–3724., doi:10.1172/jci64628.

11 Caterina, Michael J. “TRP Channel Cannabinoid Receptors in Skin Sensation, Homeostasis, and inflammation.” ACS Chemical Neuroscience 5, no. 11 (2014) : 1107–1116., doi:10.1021/cn5000919.

12 Hammell, D.c., et al. “Transdermal Cannabidiol Reduces Inflammation and Pain-Related Behaviours in a Rat Model of Arthritis.” European Journal of Pain 20, no. 6 (2015) : 936–948., doi:10.1002/ejp.818.

13 Nagarkatti, Prakash, et al. “Cannabinoids as Novel Anti-Inflammatory Drugs.” Future Medicinal Chemistry 1, no. 7 (2009) : 1333–1349., doi:10.4155/fmc.09.93.

14 Peres, Fernanda F., et al. “Cannabidiol as a Promising Strategy to Treat and Prevent Movement Disorders?” Frontiers in Pharmacology 9 (2018), doi:10.3389/fphar.2018.00482.

15 Rieder, Sadiye Amcaoglu, et al. “Cannabinoid-InducedApoptosis in Immune Cells as a Pathway to Immunosuppression.” Immunobiology 215, no. 8 (2010) : 598–605., doi:10.1016/j.imbio.2009.04.001.

16 Iffland, Kerstin, and Franjo Grotenhermen. “An Update on Safety and Side Effects of Cannabidiol:A Review of Clinical Data and Relevant Animal Studies.” Cannabis and Cannabinoid Research 2, no. 1 (June 2017): 139–154., doi:10.1089/can.2016.0034.

17 Benowitz, Neal L. “Nicotine Addiction.” New England Journal of Medicine 362, no. 24 (2010): 2295–2303., doi:10.1056/nejmra0809890.

18 Shannon, Scott. “Cannabidiol in Anxiety and Sleep: A Large Case Series.” The Permanente Journal (2019), doi:10.7812/tpp/18-041.

19 Stanley, Christopher P., et al. “Is the Cardiovascular System a Therapeutic Target for cannabidiol?”British Journal of Clinical Pharmacology 75, no. 2 (2013): 313–322., doi:10.1111/j.1365-2125.2012.04351.x.

20 Horváth, Béla, et al. “The Endocannabinoid System and Plant-Derived Cannabinoids in Diabetes and Diabetic Complications.” The American Journal of Pathology 180, no. 2 (2012): 432–442., doi:10.1016/j.ajpath.2011.11.003.

21 Kaplan, Barbara L.f., et al. “The Profile of ImmuneModulation by Cannabidiol (CBD) Involves Deregulation of Nuclear Factor of Activated T Cells (NFAT).” Biochemical Pharmacology 76, no. 6 (2008): 726–737., doi:10.1016/j.bcp.2008.06.022.

22 Rimmerman, N, et al. “Direct Modulation of the Outer Mitochondrial Membrane Channel,Voltage-Dependent Anion Channel 1 (VDAC1) by Cannabidiol: a Novel Mechanism for Cannabinoid-Induced Cell Death.” Cell Death & Disease 4,no. 12 (2013), doi:10.1038/cddis.2013.471.

23 Mersiades, Antony J, et al. “Oral Cannabinoid-Rich THC/CBD Cannabis Extract for SecondaryPrevention of Chemotherapy-Induced Nausea and Vomiting: a Study Protocol for aPilot and Definitive Randomised Double-Blind Placebo-Controlled Trial(CannabisCINV).” BMJ Open 8, no. 9 (2018), doi:10.1136/bmjopen-2017-020745.

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